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KMID : 0043320090320091211
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Archives of Pharmacal Research
2009 Volume.32 No. 9 p.1211 ~ p.1214
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2-Hydroxydiplopterol, A New Cytotoxic Pentacyclic Triterpenoid from the Halotolerant Fungus Aspergillus variecolor B-17
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Zhu Wei Ming
Wang Wen-Liang
Liu Pei Pei
Zhang Ya-Peng
Li Jing
Tao Hong-Wen
Gu Qian-Qun
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Abstract
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A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC50 value of 22 μM.
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KEYWORD
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Halotolerant fungus, Aspergillus variecolor, Cytotoxic triterpenoid, 2-Hydroxydiplopterol
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